In South Asian Social Castes, A Dwelling Lab For Genetic Ailment

In previous studies, Dr. Reich, Dr. Thangaraj and colleagues found that social groups in South Asia mixed between around 4,000 and 2,000 years ago.
But populations like those found across South Asia provide a powerful opportunity to study how gene changes manifest naturally in humans.
“You can see writ in the genome the effects of this intense endogamy,” Dr. Reich said.
Today, 14 groups with these genetic profiles in South Asia have estimated census sizes of over one million.
Advertisement Continue reading the main storyThis distinction is important because it’s well documented that marriage between close relatives can increase the possibilities of recessive disease.

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